PhD position in RNA structure computational analysis neural sublocalization of transcripts

We have a PhD position available in the Gorodkin lab at the Section for Health Data Science and AI at the Department of Public Health, Faculty of Health and Medical Sciences at University of Copenhagen. The project concerns the development of a predictive computational framework for understanding the subcellular localization of polyadenylated RNAs in neurons, including mRNAs and long noncoding RNAs.

The project will integrate RNA sequence, structure, RNA-binding protein interactions, and biological function to uncover the rules governing RNA localization in healthy, degenerating, and regenerating neurons. Start date is February 1, 2027.

Principal supervisor is Professor Jan Gorodkin, Department of Public Health, gorodkin@sund.ku.dk phone +45 23375667 The project The project aims to develop a predictive computational framework for neuronal RNA localization by combining RNA sequence and structure information with RNA-binding protein (RBP) interactions and biological function.

The framework will use data on endogenous and designed RNAs in healthy, degenerating, and regenerating neurons. The project will integrate existing datasets on neuronal RNA localization, including Frac-seq and N-zip data, with RNA structure and RBP-binding information1 …