Postdoc in in silico systems and structural biology of mammalian cell lines for biotherapeutic protein production - DTU Bioengineering

Join our team as a computational postdoctoral researcher and help design the next generation of mammalian cell lines for biotherapeutic production. While the biopharma industry relies heavily on mammalian cells to produce complex medicines, they remain metabolically inefficient, necessitating costly, highly complex nutrient feeds.

Our project aims to break this dependency by mapping and restoring lost metabolic capabilities directly within these production cell lines. By driving the in silico pathway design and systems-level data analysis, you will guide our experimental engineering to fundamentally simplify biomanufacturing, slash production costs, and enhance the global accessibility of life-saving biotherapeutics.

Responsibilities and qualifications The postdoctoral researcher will lead the computational efforts to design and analyze the rewiring of mammalian cell metabolism. Your core responsibilities will include:

Pathway design and metabolic modeling:

• Utilize genome-scale metabolic models to design and simulate essential amino acid biosynthetic pathways in silico.
• You will integrate and analyze experimental data (e.g., growth, transcriptomic, and metabolomic) from engineered lines through the lens of these models to iteratively identify and refine engineering targets1 …